Tissue Extracellular Matrix (ECM)

Every body has the power to heal

ECM Key Learnings
  •  Present in all tissues and functions as the biological scaffold for cells
  • Contains structural, adhesion and signalling molecules
  • Tissue function and healing are dependent on the ECM
  • The ECM is damaged or missing in wounds
  • ECM is not a bystander during healing, but actively scaffolds and directs cells
  • Wound healing can be augmented by replacing the missing or damaged ECM
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The essential tissue network

The extracellular matrix (ECM) is the material found around and between cells binding them together, and is made up mostly of collagen along with other proteins.[1, 2]
The ECM provides a structural scaffold
to the body’s tissues and organs, such as the skin, and is a critical platform for ongoing, dynamic and reciprocal communication and signalling between cells.[1, 3]
The ECM and its associated components play key roles in orchestrating communication that directs incoming cells to grow, divide, move and attach.

ECM is essential to the health of tissues and to the tissue repair process